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Evidence is increasing that addiction without exception is related to difficulties with the brain's reward center, particularly the mesolimbic system. This part of the problem regulates reward responses in acquiring food and sex, along with nurturing infants and children. One of the most important neurotransmitters associated with reward responses, both once they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in in reaction to a stimulus"(Bostwick & Bucci, 2008). Using two separate drugs to shed pounds can be very effective you'll find combinations as you're watching FDA now awaiting approval. When dealing with fat loss and the individuals who go through it you should err along the side of caution and permit the FDA do its job and demand some research be done in order that the public recognizes the side effects and dangers of the medications before we take them. Keep in mind that drug companies are in business to generate income and that they would say almost anything to keep people on the medications. Researchers found that participants taking this drug for any year, lost weight within four weeks and have kept the weight off through the entire 56 weeks from the study. Contrave is a combination of the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs which are made up of multiple active ingredient, which may make them far better and safer. Combo-pilling could be the newest fad or even better the newest ahead under scrutiny and thus it is just more publicly known in recent months, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills is becoming popular is the fact that by right now there are not any long term prescription weightloss pills that have been licensed by the FDA apart from orlistat. The truly disturbing part is always that doctors are prescribing these combinations of medications even though some of the combinations have been rejected or have yet to be authorized by the FDA. Seizures certainly are a side effect with Contrave and really should not be taken in individuals with seizure disorders. The drug also can raise hypertension and pulse rate, and mustn't be used in individuals with a history of heart attack or stroke in the last six months. Blood pressure and pulse should also be measured prior to starting the drug and throughout therapy with all the drug. The FDA also warned that Contrave can raise hypertension and heart rate and must not used in patients with uncontrolled high blood pressure level, as well as by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting mental performance) disease. Patients having a history of heart attack or stroke in the last six months, life-threatening arrhythmias, or congestive heart failure were excluded from the clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, considering that the compound includes bupropion, Contrave comes having a boxed warning to alert physicians and patients for the increased probability of suicidal thoughts and behaviors related to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stopping smoking. "This may be the first drug I'm mindful of that targets the two appetite and reward centres in the brain," he was quoted saying.